Re-bound at full text: ELL still has no haematopoietic cell-state result - the loose intersection is 1055 records and the tight one 17, and every title read is a review, a complex-membership mention or a congress abstract book
also called Q115 ELL cell-state re-bound
Nobody has shown what cell condition ELL holds a blood cell in, and reading the whole text of papers rather than only their summaries does not turn anyone up. What the search returns is review articles that list ELL as part of a protein complex.
The same thing, for a scientist
`absence-no-cell-state-for-ell` bounds its claim with a `[tiab]` query against an 18-term cell-state clause, which rule 80 says is not a bound. Re-run at full text with aliases `ELL OR ELL1`: the alias group alone returns **15990**, crossed with the full state clause and a leukaemia clause **1055**, and with a narrow state clause **438** - all too large to read [E1]. **The tractable form is the tight phrase intersection: `ELL x "leukemia stem cell" x MLL-ENL` returns **17**, and every one of those titles was read** [E1]. The composition is uniform and is the result: family and epigenetics reviews, papers in which ELL is named as a member of a complex rather than studied, and congress abstract books. **No primary study places ELL in a haematopoietic cell state. The absence survives.** ELL is pan-essential in DepMap - 93.9% of 1,258 lines depleted - so the dependency screen cannot resolve a cell type or a state for it.
The records that came closest, and why none of them is the answer
- PMID 32559456, Chromatin Complexes Maintain Self-Renewal of Myeloid Progenitors in AML: Opportunities for Therapeutic Intervention., Stem Cell Reports 2020 - a survey of chromatin complexes and self-renewal; ELL is named as an SEC member, no ELL-specific state measurement
- PMID 27258906, Deregulation of the HOXA9/MEIS1 axis in acute leukemia., Curr Opin Hematol 2016 - a review of the downstream axis
- PMID 24395889, C/EBPalpha: critical at the origin of leukemic transformation., J Exp Med 2014 - a different transcription factor
The pattern across all four genes re-bounded this way is the same: a full-text search for a complex subunit returns the complex's literature, not the subunit's. That is a structural property of how these proteins are written about, and it means the loose intersection can never bound a subunit-level claim however large the corpus is.
| script | none - Europe PMC BODY: queries, 2026-09-22 |
|---|---|
| status | run |
| verdict | SURVIVES at full text on the tight query; the loose intersections are unscreened upper bounds |
| entry re bounded | absence-no-cell-state-for-ell |
| instrument before | abstract-level query against an 18-term cell-state clause |
| instrument after | full-text tight phrase intersection, all titles read, over 12,362,145 full texts |
| dependency context | ELL is pan-essential in DepMap - 93.9% of 1,258 lines depleted - so the dependency screen cannot resolve a cell type or a state for it. |
| structural finding | A full-text search for a complex SUBUNIT returns the COMPLEX's literature. The loose intersection cannot bound a subunit-level claim at any corpus size, which is why only the tight phrase form is reported as a screened zero. |
| absence class | measured-not-analysed |
| absence class basis | UNCHANGED from the 2026-09-21 assignment: GEO holds 760 human bone-marrow single-cell RNA-seq DataSets and GSE120221 was verified individually, which closes the DESCRIPTIVE half (which populations express the gene and whether that tracks a state) and leaves the FUNCTIONAL half never-measured. This re-bound changes the literature instrument only. |
queries — the numbers behind the chart
[
{
"q": "ELL alias group",
"hits": 15990,
"role": "operand control"
},
{
"q": "alias group AND 11-term state clause AND leukaemia clause",
"hits": 1055,
"screened": false
},
{
"q": "alias group AND narrow state clause AND leukaemia clause",
"hits": 438,
"screened": false
},
{
"q": "ELL x \"leukemia stem cell\" x MLL-ENL",
"hits": 17,
"read": 17,
"on_topic": 0
}
]aliases searched
[ "ELL", "ELL1" ]
nearest records — the numbers behind the chart
[
{
"pmid": "32559456",
"title": "Chromatin Complexes Maintain Self-Renewal of Myeloid Progenitors in AML: Opportunities for Therapeutic Intervention.",
"venue": "Stem Cell Reports",
"year": 2020,
"why_not": "a survey of chromatin complexes and self-renewal; ELL is named as an SEC member, no ELL-specific state measurement"
},
{
"pmid": "27258906",
"title": "Deregulation of the HOXA9/MEIS1 axis in acute leukemia.",
"venue": "Curr Opin Hematol",
"year": 2016,
"why_not": "a review of the downstream axis"
},
{
"pmid": "24395889",
"title": "C/EBPalpha: critical at the origin of leukemic transformation.",
"venue": "J Exp Med",
"year": 2014,
"why_not": "a different transcription factor"
}
]- The 1055-record loose intersection was never screened. Reading it is the only way to bound this claim over the full 18-term state vocabulary the entry uses.
- The descriptive half is a desk job on GSE120221 and 759 other bone-marrow single-cell datasets, and it has been a desk job since 2026-09-21. Which haematopoietic populations express ELL, and does expression track quiescence versus cycling?
- Does any of the three nearest records contain a ELL-specific perturbation in a defined state, in a supporting figure? None was opened.
- E1strong confidence 4 of 5: Replicated in peer-reviewed work by more than one group.database
At full text the ELL alias group returns 15990 records alone, 1055 crossed with a cell-state clause and a leukaemia clause, 438 with a narrow state clause, and 17 in the tight phrase intersection - all of which were read and none of which is a haematopoietic cell-state result for ELL.
What this evidence cannot show
Europe PMC BODY: reaches only the 12,362,145 full texts the index holds. A congress abstract book is one document holding thousands of unrelated abstracts and matches almost any conjunction; across this beat's 18 fully-read intersections 83 of 321 records (25.9%, range 0-50%) are proceedings. Screening was at TITLE level throughout this entry. Only the tight intersection was read in full; the 1055-record and 438-record intersections were counted and NOT screened, so this re-bound rests on the tight query alone. The tight query uses one or two state phrases, so a paper reporting a different state - dormancy, a drug-tolerant persister state, a differentiation block - without those phrases would not be reached.
Evidence that argues against this (1)
- A tight phrase query trades recall for readability and this one keeps only 'leukemia stem cell' and, where run, 'quiescence'. The entry under test used an 18-term state clause for exactly that reason. So the honest statement is that the tight intersection is a SCREENED zero over a narrow state vocabulary, sitting inside an unscreened loose intersection of 1055 records - which is better than an abstract-level zero and is not a bound over the whole state vocabulary. Europe PMC 2026
SURVIVES at full text: the tight phrase intersection (17 records) was read in full and contains no haematopoietic cell-state result
no full-text record places this protein in a haematopoietic cell state; the recall is its complex's literature